Effectiveness & Testimonials
Cryoablation has shown promising results in treating early-stage, hormone-sensitive breast cancers. The procedure involves using extreme cold to freeze and destroy cancerous tissues, offering a less invasive alternative to traditional surgeries like lumpectomy or mastectomy.
Cryoablation Improves Patient Satisfaction
Effective & Safe
Cancer control equal to lumpectomy for early stage breast cancer
Physical Well-being
Less pain or tightness and less difficulty with mobility, such as lifting arms.
Sexual Well-being
Greater feelings of sexual attractiveness, sexual confidence, and comfort level during sex
Satisfaction with Breasts
Greater happiness about breast size, how bras fit, and appearance in the mirror clothed or unclothed, as well as how the breasts feel to the touch.
Clinical Effectiveness of Cryoablation
Studies have highlighted the following key findings:
- Efficacy for Small Tumors: Cryoablation is most effective for tumors 2 cm or smaller. The American College of Surgeons Oncology Group (ACOSOG) Z1072 trial reported a 100% success rate for tumors less than 1 cm and a 92% success rate for tumors up to 2 cm.
- Long-Term Success: A Japanese clinical trial involving 304 women with stage I invasive ductal carcinomas reported a 0.98% local recurrence rate over six years, demonstrating the long-term effectiveness of cryoablation when combined with anti-estrogen medications and radiation therapy.
- In April 2024, the 5-year follow-up results of the ICE3 trial were presented at the annual meeting of the American Society of Breast Surgeons in Orlando, Florida. The ICE3 trial is multicenter, single-arm, non-randomized clinical trial that evaluated the role of cryoablation as an alternative to surgery. The trial enrolled 194 women years of age (median 75 years) with unifocal, clinical stage I, histologic grade 1 or 2, estrogen receptor positive, progesterone receptor positive, HER2/neu negative invasive ductal carcinoma diagnosed by minimally invasive biopsy. The use of anti-estrogen therapy, radiation therapy, and sentinel node biopsy were not mandated by the trial. As such, nearly 80% of ICE3 trial participants utilized endocrine therapy but only 14% received adjuvant radiation therapy and only 8% of participants underwent a sentinel node biopsy. At 5 years of follow-up, there were 7 recurrences of cancer in the same breast yielding a local recurrence free survival rate of 96.7%, which is comparable to lumpectomy clinical trials in women over 60 years of age where radiation therapy was omitted. The 5-year results will be published soon.
Cryoablation also offers theoretical benefits in stimulating an anti-cancer immune response, although this effect is not yet fully proven in humans. Proteins released from cryoablated tumors may help the immune system recognize and attack remaining cancer cells, potentially providing additional protection against recurrence.
Quick, Minimally Invasive, and Highly Effective.
Effectiveness in killing targeted cancer cells.
Average duration of the cryoablation procedure.
Typical recovery time before resuming normal activites.
Local recurrence rate in patients over a 6-year folow-up.
Real Stories from Dr. Holmes’ Patients
Every I could want from a breast surgeon and more. Patient, informative, gentle, thorough.
Margaret S.
Patient
Dr. Holmes and Alba have been great thru this whole experience. I could not ask for a better team.
Alison E.
Patient
I was very at easy with Dr Homes and his staff when dealing with a potentially scary situation. I’m truly grateful for their care.
Nicole F.
Patient
I had the best experience with Dr. Holmes and Elba, whenever I needed an urgent appointment I was able to get the appointment right away and received the best care from Dr. Holmes. Him being very calm helped me to stay calm and not panic and trust him. I am thankful to God for bringing Dr. Holmes into my life for this journey. I would most definitely recommend Dr. Holmes to everyone.
Magda O.
Patient
He was very attentive and listened to all of my questions.
Kathleen Q.
Patient
Dr. Holmes is one of the best surgical oncologist I have consulted with. He is on the leading edge of research for finding the best way to treat breast cancer with the least amount of damage. He is very caring and takes the time to listen to you as a patient. He has a rare gift for diagnosing that sets him apart from other doctors in his field.
Malia K.
Patient
The best doctor ever from all points, he is patient, understanding, answers all questions even the questions you don't ask. I really thank God that I have such a wonderful doctor.
Yvonne H.
Patient
Dr. Dennis Holmes is an exceptionally competent, brilliant, compassionate, caring oncologist/ breast surgeon, who ultimately offers the BEST & most promising outcome that encompasses the entire spectrum of a women’s health physically, mentally and emotionally. (Statistics documented in Japan show highest efficacy rates). Cryoablation: Non - invasive procedure that supersedes [ALL standard protocols by-“NON advanced and NOT so privy breast specialist Dr.s”] Dr. Holmes is a giant step ahead of the rest and offers the best options for women with early stage breast cancer. Cora Levine 2018/2019
Cora L.
Patient
Dr Holmes is top notch! He’s experienced, wise, caring and thorough. He’s busy, but well worth the wait! Highly recommend him.
Mary Ann B.
Patient
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