Effectiveness & Testimonials
Cryoablation has shown promising results in treating early-stage, hormone-sensitive breast cancers. The procedure involves using extreme cold to freeze and destroy cancerous tissues, offering a less invasive alternative to traditional surgeries like lumpectomy or mastectomy.
Clinical Effectiveness of Cryoablation
Studies have highlighted the following key findings:
- Efficacy for Small Tumors: Cryoablation is most effective for tumors 2 cm or smaller. The American College of Surgeons Oncology Group (ACOSOG) Z1072 trial reported a 100% success rate for tumors less than 1 cm and a 92% success rate for tumors up to 2 cm.
- Long-Term Success: A Japanese clinical trial involving 304 women with stage I invasive ductal carcinomas reported a 0.98% local recurrence rate over six years, demonstrating the long-term effectiveness of cryoablation when combined with anti-estrogen medications and radiation therapy.
- In April 2024, the 5-year follow-up results of the ICE3 trial were presented at the annual meeting of the American Society of Breast Surgeons in Orlando, Florida. The ICE3 trial is multicenter, single-arm, non-randomized clinical trial that evaluated the role of cryoablation as an alternative to surgery. The trial enrolled 194 women years of age (median 75 years) with unifocal, clinical stage I, histologic grade 1 or 2, estrogen receptor positive, progesterone receptor positive, HER2/neu negative invasive ductal carcinoma diagnosed by minimally invasive biopsy. The use of anti-estrogen therapy, radiation therapy, and sentinel node biopsy were not mandated by the trial. As such, nearly 80% of ICE3 trial participants utilized endocrine therapy but only 14% received adjuvant radiation therapy and only 8% of participants underwent a sentinel node biopsy. At 5 years of follow-up, there were 7 recurrences of cancer in the same breast yielding a local recurrence free survival rate of 96.7%, which is comparable to lumpectomy clinical trials in women over 60 years of age where radiation therapy was omitted. The 5-year results will be published soon.
Cryoablation also offers theoretical benefits in stimulating an anti-cancer immune response, although this effect is not yet fully proven in humans. Proteins released from cryoablated tumors may help the immune system recognize and attack remaining cancer cells, potentially providing additional protection against recurrence.
Quick, Minimally Invasive, and Highly Effective.
Effectiveness in killing targeted cancer cells.
Average duration of the cryoablation procedure.
Typical recovery time before resuming normal activites.
Local recurrence rate in patients over a 6-year folow-up.
Real Stories from Dr. Holmes’ Patients
Front desk girls are very helpful very polite very understanding and taking care of the patient. This was my first time visit with Dr Holmes and I found him to be very thorough.
Terri S.
Patient
I am very happy to be able to have Dr. Holmes as my surgeon. He is great - a real doctor, who is sincerely concerned with his patients’ well being. He is knowledgable, kind and easy to communicate with. His office staff is professional and efficient.
Bella D.
Patient
Dr. Holmes and his staff are in a class all by themselves. Exceptional in every way. I am so grateful to Yahovah for an amazing doctor and staff. God bless you all!
Robin W.
Patient
My doctor referred me to doctor Holmes and it was the best thing for me. He is very detailed and explains every question I had, very nice , compassionate and knowledgeable. I know I am in good hands
Violeta G.
Patient
Presented options I was not aware of and gave me hope
Pamela K.
Patient
I personally have not had to be treated by Dr. Holmes, but I took my cousin for her treatments/surgery. Dr. Holmes is phenomenal! I have also recommended him to other women who are feeling so blessed to have him on their side during this tough time. Bless Dr. Holmes! Thank you.
Joan J.
Patient
Dr.Holmes is an amazing caring and knowledgeable person. I trusted him and now I am cancer free. Thank you Doc. God bless you
Asya A.
Patient
Excellent and he listens well and advices options.
Kimberly B.
Patient
Dr. Dennis Holmes is an outstanding doctor. He is caring, personable and very easy to talk with. He is extremely knowledgeable and a leader in the field of breast cancer care. After being diagnosed with breast cancer I was told that the standard procedure with my type of cancer was a lumpectomy, radiation and possible chemotherapy with a hormone blocker which to me was devastating. I researched alternatives on my own and when I found Dr. Dennis Homes I was so grateful! He provided a cure for my cancer, cryoablation, that was much more endurable, minimally-invasive and cared about my emotional needs while managing my problem effectively. He gave me hope that I can get through this! His office staff is the best! Allison, who I interacted with a lot for appointments, questions to the doctor and whatever I needed always responded quickly, efficiently and with such kindness. I highly recommend Dr. Holmes and will be forever thankful for him and his staff!
Lorine C.
Patient
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