Effectiveness & Testimonials
Cryoablation has shown promising results in treating early-stage, hormone-sensitive breast cancers. The procedure involves using extreme cold to freeze and destroy cancerous tissues, offering a less invasive alternative to traditional surgeries like lumpectomy or mastectomy.
Clinical Effectiveness of Cryoablation
Studies have highlighted the following key findings:
- Efficacy for Small Tumors: Cryoablation is most effective for tumors 2 cm or smaller. The American College of Surgeons Oncology Group (ACOSOG) Z1072 trial reported a 100% success rate for tumors less than 1 cm and a 92% success rate for tumors up to 2 cm.
- Long-Term Success: A Japanese clinical trial involving 304 women with stage I invasive ductal carcinomas reported a 0.98% local recurrence rate over six years, demonstrating the long-term effectiveness of cryoablation when combined with anti-estrogen medications and radiation therapy.
- In April 2024, the 5-year follow-up results of the ICE3 trial were presented at the annual meeting of the American Society of Breast Surgeons in Orlando, Florida. The ICE3 trial is multicenter, single-arm, non-randomized clinical trial that evaluated the role of cryoablation as an alternative to surgery. The trial enrolled 194 women years of age (median 75 years) with unifocal, clinical stage I, histologic grade 1 or 2, estrogen receptor positive, progesterone receptor positive, HER2/neu negative invasive ductal carcinoma diagnosed by minimally invasive biopsy. The use of anti-estrogen therapy, radiation therapy, and sentinel node biopsy were not mandated by the trial. As such, nearly 80% of ICE3 trial participants utilized endocrine therapy but only 14% received adjuvant radiation therapy and only 8% of participants underwent a sentinel node biopsy. At 5 years of follow-up, there were 7 recurrences of cancer in the same breast yielding a local recurrence free survival rate of 96.7%, which is comparable to lumpectomy clinical trials in women over 60 years of age where radiation therapy was omitted. The 5-year results will be published soon.
Cryoablation also offers theoretical benefits in stimulating an anti-cancer immune response, although this effect is not yet fully proven in humans. Proteins released from cryoablated tumors may help the immune system recognize and attack remaining cancer cells, potentially providing additional protection against recurrence.
Quick, Minimally Invasive, and Highly Effective.
Effectiveness in killing targeted cancer cells.
Average duration of the cryoablation procedure.
Typical recovery time before resuming normal activites.
Local recurrence rate in patients over a 6-year folow-up.
Real Stories from Dr. Holmes’ Patients
Extremely professional and thorough.
Nellie F.
Patient
Excellent care - my concerns were taken seriously. I felt heard and well taken care of.
Kelly L.
Patient
Dr. Dennis Holmes MD, is an outstanding Clinician and Board Certified Oncology Breast Surgeon Speacialist. He is very kind, patient, and compassionate as a health care clinician who provides care that incorporates minimally invasive and many innovative breast surgical techniques. His approach to treating breast cancer surgically is primarily aimed not only at simply removing breast cancer cells from the body but he strives to uplift and provide hope to all women undergoing breast cancer surgery as a whole, with a detailed care plan to include rapid recovery time, minimal pain, and minimized scars. He is very attentive to details and excellent at providing smooth continuity of care in a uniquely advanced and profound way. Dr. Holmes you are truly Heaven Sent. May God continue to Bestow His Blessings upon you with the craftsmanship and the ability to touch, heal, and to restore health in the lives of many patients with your expertise and knowledgebase within this challenging field of healthcare at which you are definitely leading the way. Sincerely
D J.
Patient
Dr Holmes is top notch! He’s experienced, wise, caring and thorough. He’s busy, but well worth the wait! Highly recommend him.
Mary Ann B.
Patient
Dr. Dennis Holmes is an exceptionally competent, brilliant, compassionate, caring oncologist/ breast surgeon, who ultimately offers the BEST & most promising outcome that encompasses the entire spectrum of a women’s health physically, mentally and emotionally. (Statistics documented in Japan show highest efficacy rates). Cryoablation: Non - invasive procedure that supersedes [ALL standard protocols by-“NON advanced and NOT so privy breast specialist Dr.s”] Dr. Holmes is a giant step ahead of the rest and offers the best options for women with early stage breast cancer. Cora Levine 2018/2019
Cora L.
Patient
The best doctor ever from all points, he is patient, understanding, answers all questions even the questions you don't ask. I really thank God that I have such a wonderful doctor.
Yvonne H.
Patient
Dr. Holmes is one of the best surgical oncologist I have consulted with. He is on the leading edge of research for finding the best way to treat breast cancer with the least amount of damage. He is very caring and takes the time to listen to you as a patient. He has a rare gift for diagnosing that sets him apart from other doctors in his field.
Malia K.
Patient
He was very attentive and listened to all of my questions.
Kathleen Q.
Patient
I had the best experience with Dr. Holmes and Elba, whenever I needed an urgent appointment I was able to get the appointment right away and received the best care from Dr. Holmes. Him being very calm helped me to stay calm and not panic and trust him. I am thankful to God for bringing Dr. Holmes into my life for this journey. I would most definitely recommend Dr. Holmes to everyone.
Magda O.
Patient
Submit Your Case
We invite you to submit your case for a free case preview with Dr. Dennis Holmes. Our goal is to make the process as easy and accessible as possible, ensuring you get the information and support you need.
